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Louisiana Took Months To Sound Alarm After Two Babies Died in Whooping Cough Outbreak

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When there’s an outbreak of a vaccine-preventable disease, state health officials typically take certain steps to alert residents and issue public updates about the growing threat. That’s standard practice, public health and infectious disease experts told KFF Health News and NPR. The goal is to keep as many other vulnerable people as possible from getting sick and to remind the public about the benefits of vaccinations.

But in Louisiana this year, public health officials appeared to have not followed that playbook during the state’s worst whooping cough outbreak in 35 years.

Whooping cough, also called pertussis, is a highly contagious, vaccine-preventable disease that’s particularly dangerous for the youngest infants. It can cause vomiting and trouble breathing, and serious infections can lead to pneumonia, seizures, and, rarely, death.

Madison Flake, a pediatric resident in Baton Rouge, cared for a baby who was hospitalized during this year’s outbreak. Less than 2 months old, he was sent to the intensive care unit.

“He would have these bouts of very dramatic coughing spells,” Flake said. “He would stop breathing for several seconds to almost a minute.”

Infants are not eligible for their first pertussis vaccine until they are 2 months old, but they can acquire immunity if the mother is immunized while pregnant.

By late January, two babies had died in Louisiana.

But the Louisiana Department of Health waited two months to send out a social media post suggesting people talk to their doctors about getting vaccinated. The department took even longer to issue a statewide health alert to physicians, send out a press release, or hold a news conference.

That lag is not typical, according to Georges Benjamin, the executive director of the American Public Health Association.

“Particularly for these childhood diseases, we usually jump all over these,” said Benjamin, a physician who has led health departments in Maryland and Washington, D.C. “These are preventable diseases and preventable deaths.”

Because infectious diseases spread exponentially, if officials don’t alert the public quickly, they lose a key chance to prevent further infections, said Abraar Karan, an instructor at Stanford University who has worked on covid and mpox outbreaks.

“Time is perhaps one of the most important currencies that you have,” he added.

General Promotion of Vaccines Banned

Because pertussis vaccine immunity wanes over time, cases can ebb and flow. But in September 2024, Louisiana health officials started seeing a “substantial” increase in whooping cough cases, part of a national trend.

In late January, physicians at one Louisiana hospital warned their colleagues that two infants had died in the outbreak.

On Feb. 13, the state’s surgeon general, Ralph Abraham, sent a memo to staff ending the general promotion of vaccines and community vaccine events.

He sent that email a few hours after Robert F. Kennedy Jr., an anti-vaccine activist, won Senate confirmation as the new secretary of the U.S. Department of Health and Human Services.

Also that day, Abraham posted a public memo on the state health department’s website. In it, he said public health has overstepped with vaccine recommendations, driven by “a one-size-fits-all, collectivist mentality.” Abraham has called covid vaccines “dangerous” and been a vocal supporter of Kennedy.

Four days later, in response to a request from WVUE Fox 8 News in New Orleans, the Louisiana Department of Health in an email confirmed the deaths of two infants from whooping cough for the first time. WVUE published the news on Feb. 20.

But Louisiana’s health department sent out no alerts, according to a review of external and internal communications by NPR and KFF Health News.

Over the next month, two more infants were hospitalized for whooping cough, according to internal health department emails obtained through a public records request.

In March, after inquiries from NPR and KFF Health News about the growing number of pertussis cases, the department put out its first social media communications about the outbreak and offered interviews to other journalists.

Then on May 1 — at least three months after the second infant death — the health department issued what appears to be its first and so far only official alert to physicians. It put out its first press release the next day and then held a news conference about pertussis on May 14.

By then, 42 people had been hospitalized for whooping cough since the outbreak began, three-quarters of whom were not up to date on their whooping cough immunizations, according to the Louisiana Department of Health.

More than two-thirds of those hospitalized were babies under the age of 1.

Throughout the summer, pertussis cases continued to climb in Louisiana. But there were no further public communications from the state health department.

NPR and KFF Health News contacted the department for comment on Sept. 25. Emma Herrock, a spokesperson, did not answer specific questions about the lack of communications but referred to a Sept. 30 post on X by the state surgeon general.

In the post, Abraham said the department “consistently reported cases of pertussis and provided guidance to help residents stay protected” in 2025. He called the pertussis vaccine “one of the least controversial” and said he recommends it to his patients.

The X post included a year-by-year graphic of pertussis cases that omitted 2024 and 2025. The post also provided a more specific timeframe for when the infant deaths occurred — one in late 2024 and the other in early 2025.

Whooping cough, also called pertussis, is a highly contagious, vaccine-preventable disease that’s particularly dangerous for the youngest infants.(Brianna Soukup/Portland Portland Press Herald via Getty Images)

A ‘Train Wreck’ of Cases

Louisiana should have started warning the public within days of the first infant’s death instead of waiting months, said Stanford’s Karan.

“At minimum,” he said, “it should be like heavy promotion of: ‘Hey, infants are at high risk. They get infected by people who have waning immunity. If you haven’t gotten vaccinated, get vaccinated. If you have these symptoms, get tested.’”

Deaths from a vaccine-preventable illness are tragic, but they can also serve as an opportunity to educate the public about the benefits of vaccines and try to save lives, said Joshua Sharfstein, a former Maryland health secretary and now a professor at the Johns Hopkins Bloomberg School of Public Health.

“The risk of pertussis is always there, but when you have two infant deaths it’s a really good opportunity to communicate that this is a real threat to the health of children,” Sharfstein said.

Karan said that by not acting more quickly, the Louisiana Department of Health may have set itself up for a worse outbreak.

“Because then what we see is this train wreck thereafter, of like an insanely large outbreak, a lot of hospitalizations,” he said.

The Outbreak Continued

As of Sept. 20, the most recent date for which data is available, Louisiana had counted 387 cases of whooping cough in 2025, according to the Centers for Disease Control and Prevention. In data going back to 1990, the previous high was 214 cases, in 2013.

Until the Sept. 30 post on X, the Louisiana Department of Health did not appear to put out any public communications about pertussis over the preceding four months, though hospitalizations continued and case levels surpassed the 2013 levels.

The health department should be responding aggressively and consistently, said Joseph Bocchini, the president of the Louisiana Chapter of the American Academy of Pediatrics.

Health officials should make sure “people are updated on a regular basis and reminded of what needs to be done,” he said. “Get your vaccines. Moms, if you’re pregnant, get vaccinated. And if you have a cough illness, see your doctor.”

Benjamin, with the American Public Health Association, said the ongoing goal of public health communication is to prevent the next hospitalization or death.

“The bottom line is, it’s not too late,” he said. “It’s not too late to be much more aggressive and proactive about dealing with pertussis.”

This article is from a partnership that includes WWNO, NPR, and KFF Health News.

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AI can speed antibody design to thwart novel viruses

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Cryogenic electron microscopy (cryo-EM) resolution of the structure of a respiratory syncytial virus fusion protein (shades of pink) bound to fragments of two antibodies (dark/light and blue/green) designed by the researchers’ protein language model, MAGE. Wasdin et al., Generation of antigen-specific paired-chain antibodies using large language models. Credit: Cell DOI: 10.1016/j.cell.2025.10.006.

Artificial intelligence (AI) and “protein language” models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections, according to a multi-institutional study led by researchers at Vanderbilt University Medical Center.

While their report, published in the journal Cell, focuses on development of antibody therapeutics against existing and emerging viral threats, including RSV () and avian influenza viruses, the implications of the research are much broader, said the paper’s corresponding author, Ivelin Georgiev, Ph.D.

“This study is an important early milestone toward our ultimate goal—using computers to efficiently and effectively design novel biologics from scratch and translate them into the clinic,” said Georgiev, professor of Pathology, Microbiology and Immunology, and director of the Vanderbilt Program in Computational Microbiology and Immunology.

“Such approaches will have a significant positive impact on and can be applied to a broad range of diseases, including cancer, autoimmunity, , and many others,” he said.

Georgiev is a leader in the use of computational approaches to advance disease treatment and prevention. Perry Wasdin, Ph.D., a data scientist in the Georgiev lab, was involved in all aspects of the study and is the first author of the paper.

The research team, which included scientists from around the country, Australia and Sweden, showed that a protein language model could design functional human antibodies that recognized the unique antigen sequences (surface proteins) of specific viruses, without requiring part of the antibody sequence as a starting template.

Protein language models are a type of large language model (LLM), which is trained on huge amounts of text to enable language processing and generation. LLMs provide the core capabilities of chatbots such as ChatGPT.

By training their protein language model MAGE (Monoclonal Antibody Generator) on previously characterized antibodies against a known strain of the H5N1 influenza () virus, the researchers were able to generate antibodies against a related, but unseen, influenza strain.

These findings suggest that MAGE “could be used to generate antibodies against an emerging health threat more rapidly than traditional antibody discovery methods,” which require from infected individuals or antigen protein from the novel virus, the researchers concluded.

Other Vanderbilt co-authors were Alexis Janke, Ph.D., Toma Marinov, Ph.D., Gwen Jordaan, Olivia Powers, Matthew Vukovich, Ph.D., Clinton Holt, Ph.D., and Alexandra Abu-Shmais.

More information:
Perry T. Wasdin et al, Generation of antigen-specific paired-chain antibodies using large language models, Cell (2025). DOI: 10.1016/j.cell.2025.10.006

Journal information:
Cell


Citation:
AI can speed antibody design to thwart novel viruses (2025, November 6)
retrieved 6 November 2025
from https://medicalxpress.com/news/2025-11-ai-antibody-thwart-viruses.html

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Listen to the Latest ‘KFF Health News Minute’

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Oct. 30

Arielle Zionts reads the week’s news: Though 13 states cover GLP-1s such as Wegovy for weight loss for people on Medicaid, many eligible people are missing out, and advance planning can help seniors aging alone maintain more control over their final days.


Oct. 23

Sam Whitehead reads the week’s news: More men are developing osteoporosis, but insurance often won’t pay to screen them, and the Trump administration’s cuts to a digital equity program are setting back efforts to help some rural communities access telehealth.


Oct. 16

Katheryn Houghton reads the week’s news: Most states allow medical providers to force employers to send them part of a patient’s paycheck to cover unpaid medical bills, and the Trump administration’s cuts to federal funding are making flood-prone hospitals more vulnerable.


Oct. 9

Zach Dyer reads the week’s news: Some cosmetic surgeons who have been sued multiple times for injuring patients have been able to get jobs with other clinics, and millions of people could dodge new Medicaid work rules where unemployment rates are high.


Oct. 2

Sam Whitehead reads the week’s news: Hospital charity care programs can still leave patients who qualify with big bills, and the Trump administration is rolling out a pilot program to use AI to deny care for Medicare patients in six states. 


Sept. 25

Arielle Zionts reads this week’s news: Asking AI tools to interpret your lab results can have downsides, and more Americans are choosing environmentally friendly “green burials.”


Sept. 18

Zach Dyer reads the week’s news: Some independent rural hospitals are joining forces to try to survive, and public health guidance on head lice at school clashes with parents’ preferences.


Sept. 11

Jackie Fortiér reads the week’s news: Federal cuts to food assistance could make it harder for families to stay healthy, and some health insurers are planning to reduce coverage of popular but expensive weight loss drugs.


Sept. 4

Katheryn Houghton reads the week’s news: New research shows that regular, moderate use of devices like computers and smartphones can be good for the cognitive health of older people, and human resources departments can help employees get health insurance companies to pay for covered care.


Aug. 28

Sam Whitehead reads the week’s news: Emergency rooms with no doctor on staff are becoming more common in rural areas, and higher costs for Affordable Care Act plans could hit early retirees and small-business owners hard next year.


Aug. 21

Zach Dyer reads the week’s news: Some doctors are changing how they talk to patients about immunizations because of changes to federal vaccine policy, and 26 is the age with the highest uninsured rate.


Aug. 14

Jackie Fortiér reads the week’s news: Many states are making doulas more accessible, and opioid settlement money may get used to fill budget holes from federal funding cuts to Medicaid.


Aug. 7

Sam Whitehead reads the week’s news: New Trump administration policies could limit patient access to qualified medical interpreters, and physicians often miss the signs of iron deficiency in older adults.


July 31

Jackie Fortiér reads the week’s news: The Republican megabill President Donald Trump signed July 4 could lead rural health facilities to close, and previously rare mosquito-borne illnesses like dengue are on the rise in the U.S.


July 24

Sam Whitehead reads the week’s news: Affordable Care Act health plans will likely be more expensive next year, and work requirements for Medicaid recipients can be expensive and hard to navigate for enrollees.


July 17

Sam Whitehead reads the week’s news: President Donald Trump’s immigration crackdown is threatening nursing home staff, and the country’s largest health insurers say they’ll simplify the process they use to decide whether to pay for doctor-ordered care.


July 10

Zach Dyer reads the week’s news: Federal funding cuts have left some of the nation’s most popular beaches without lifeguards this summer, and new research shows vaccines are good at keeping older adults out of the hospital. 


July 3

Katheryn Houghton reads the week’s news: The Trump administration is cutting some programs intended to prevent gun violence, and seniors who don’t sign up for Medicare at age 65 can be on the hook for medical bills, even if they still have health insurance through work.


June 26

Jackie Fortiér reads the week’s news: Gatherings called “memory cafés” can help both people with dementia and their caregivers reduce depression and isolation, and the looming end of some Affordable Care Act subsidies will make ACA plans much more expensive.


June 19

Zach Dyer reads the week’s news: Cannabis use could be riskier for older adults, and research shows covid vaccines in pregnancy can protect pregnant women as well as newborns.


June 12

Sam Whitehead reads the week’s news: Inadequate communications infrastructure is harming the health of rural Americans, and ministroke symptoms may look mild but need medical treatment.


June 5

Katheryn Houghton reads the week’s news: More than 100 rural hospitals have stopped delivering babies since 2021, and the federal government failed to warn the public about a major E. coli outbreak.


May 29

Jackie Fortier reads the week’s news: New programs teach Black kids to swim competitively and help their parents learn too, and people in prison are often denied basic health care at the end of their lives.


May 22

Zach Dyer reads this week’s news: Federal funding cuts are gutting HIV prevention programs, and financial pressures are leading to the closure of clinics that provide abortion care even in states where it’s legal.


May 15

Sam Whitehead reads this week’s news: Using “elderspeak” with seniors can be harmful, and independent pharmacists worry tariffs could force them to close.


May 8

Jackie Fortiér reads this week’s news: CPR and defibrillator training can give people the skills to help others survive cardiac arrest, and doctors are using telehealth to help thousands of patients each month access abortion care in states where it’s banned.


May 1

Katheryn Houghton delivers the week’s news: A new survey finds that more Americans are hearing false claims about measles and the vaccine that prevents it, and changes to federal health funding have advocates worried the White House is deprioritizing fighting addiction.


April 24

Zach Dyer reads this week’s news: Concierge medicine could worsen the physician shortage in rural areas, and the Trump administration has canceled medical research grants that it says aren’t in line with its priorities.


April 17

Sam Whitehead reads this week’s news: Families that rely on home health aides could pay the price for the Trump administration’s anti-immigrant policies, and some local health departments are canceling scheduled services because the federal government is trying to take back health grants.


April 10

Jackie Fortiér reads this week’s news: The Trump administration is rolling back accommodations for people with disabilities, and a charity is about to wipe out $30 billion of medical debt, but that won’t stop Americans from accruing more.


April 3

Katheryn Houghton reads this week’s news: The Trump administration may stop using a “Housing First” approach to ending homelessness, and Medicaid rules can force people with disabilities not to work in order to keep services they need.


March 27

Zach Dyer delivers this week’s news: Federal regulators want to collect more data to figure out why some CT scans deliver much more radiation than others, and opposition to mRNA vaccines could end promising efforts to cure diseases including pancreatic cancer.


March 20

Jackie Fortiér reads this week’s news: Recent firings at the Centers for Disease Control and Prevention could make it harder to control infectious disease outbreaks, and hoarding disorder can be especially dangerous for older people.


March 13

Sam Whitehead reads this week’s news: Trump voters may favor government regulation to cut health care costs, and health workers are being trained on the law to deal with possible raids by Immigration and Customs Enforcement officers in health care settings.


March 6

Zach Dyer reads this week’s news: The current bird flu outbreak is gaining momentum despite mass culling of infected poultry, and the Trump administration is embracing the conservative policy playbook known as Project 2025.


Feb. 27

Katheryn Houghton reads this week’s news: Republicans in Congress are considering cuts to Medicaid, and the dietary supplement industry is hoping to cash in on RFK Jr.’s new role as head of the Department of Health and Human Services.


Feb. 20

Jackie Fortiér reads this week’s news: Some states are turning to laundromats to reach people who could qualify for programs including Medicaid and food assistance, and cross-border telehealth is helping Spanish-speaking farmworkers get care.


Feb. 13

Sam Whitehead reads this week’s news: Hospital systems are looking for ways to help people in the U.S. without legal status get care, and some schools say staffing shortages make it hard to meet the needs of students with diabetes who use continuous glucose monitors.


Feb. 6

Katheryn Houghton delivers this week’s news: Pediatricians believe a decline in childhood vaccination rates could drive a return of deadly vaccine-preventable diseases, and addiction experts say legalizing sports betting has downsides for health.


Jan. 30

Renu Rayasam delivers this week’s news: There are still no proven therapies for long covid despite more than $1 billion in federal funding, and some hospitals are assigning dogs to work alongside medical staff in hospitals to help them cope with burnout and stress.


Jan. 23

This week on the KFF Health News Minute: Stable housing is scarce for a rapidly increasing number of homeless seniors, and insurers sometimes deny coverage for prosthetic limbs by deeming them experimental or not medically necessary.


Jan. 16

This week on the KFF Health News Minute: AI tools in medicine might not save money, and credit agencies can no longer include medical debt on credit reports.


Jan. 9

This week on the KFF Health News Minute: Small interventions at the doctor’s office, such as removing a splinter, can be billed as surgeries, and billing problems with the Indian Health Service are leaving Native American communities with significantly higher medical debt than the national average.


Jan. 2

This week on the KFF Health News Minute: Hyperthermia deaths are rising, and millions of people could lose Medicaid if the incoming Republican-controlled Congress follows through on proposed cuts to federal funding.


The KFF Health News Minute is available every Thursday on CBS News Radio.

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Farmers, Barbers, and GOP Lawmakers Grapple With the Fate of ACA Tax Credits

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John Cleveland is ready to pay a lot more for his health insurance next year.

He hasn’t forgotten the pile of hospital bills that awaited him after he had a seizure while tending to customers in his Austin, Texas, barbershop four years ago. Once doctors hurriedly removed the dangerous tumor growing on his brain, a weeklong hospital stay, months of therapy, and nearly $250,000 worth of medical expenses followed.

The coverage he has purchased for years through the Affordable Care Act marketplace covered most of those bills.

“That saved my ass,” said Cleveland, who owns three barbershops across the city.

Even with Cleveland’s monthly premiums expected to soar next year — from $560 to about $682 — he will still sign up for a plan that requires him to shell out $70 if he sees a doctor and 50% of the cost for any emergency room visits. Still, Cleveland is most worried about some of his employees, who might risk going without insurance once they see the high prices.

Small-business owners are among those who stand to lose the most should Congress let the additional, generous federal subsidies put in place during the covid-19 pandemic lapse. The looming change threatens not only their own coverage but also that of their employees, who often depend on marketplace coverage.

Whether to extend the enhanced ACA subsidies that cost taxpayers billions of dollars yearly poses a serious political conundrum for Republicans. After years of unified opposition to Obamacare, the party now faces pressure from one of its most loyal constituencies, small-business owners, who will bear the brunt of rising premiums if the subsidies disappear.

Most of the roughly 20 employees who work on Justin Miller’s 113-year-old family fruit farm in rural Northern California purchase coverage through the Obamacare marketplace.

He’s agonizing over what it could mean if health insurance through the marketplace becomes unaffordable for his employees. He fears they might consider leaving his farm for a job that comes with health coverage.

“Being a small-business owner, especially in a field like ours, where it is tough work and we really understand how hard everybody works, we have to look everybody in the eyes every day,” Miller said. “Knowing that they’re going to have to pay $4,000 or $5,000 more a year to stay on their insurance is a tough pill to swallow.”

Miller says he already pays a minimum wage of $22.50 and provides sick leave, vacation, retirement, and employee housing benefits.

Adding health insurance for his employees, he said, would be too costly to keep his farm in business.

Justin Miller says he agonizes over what it could mean if health insurance through the marketplace becomes unaffordable for his employees. “Knowing that they’re going to have to pay $4,000 or $5,000 more a year to stay on their insurance is a tough pill to swallow,” he says.(Anne Chadwick Williams for KFF Health News)

GOP Pollsters Issue ACA Caution

About half of the 24 million people enrolled in Obamacare coverage are, or are employed by, small-business owners — a group that is more likely to vote Republican and overwhelmingly backed President Donald Trump in last year’s election. Farmers, dentists, real estate agents, and chiropractors are among the professions most represented among enrollees.

Even Trump’s own pollsters have found deep support for the Obamacare subsidies, warning that failing to extend them could cost Republicans in next year’s midterms.

A poll conducted last month by Republican pollster John McLaughlin found that a majority of independent voters would be less likely to vote for politicians who voted to let the enhanced tax credits expire.

Given that “approximately 4 million” people would lose coverage and premiums would “skyrocket by an average of 75%,” the poll also concluded that: “A candidate for congress who let the healthcare tax cuts expire would also be vulnerable to more pointed messages.”

Red States Benefited From the Subsidies

Some red states have seen Obamacare enrollment balloon since the federal government began offering extra help paying premiums in the form of more generous subsidies.

Texas and Florida have added 2.8 million enrollees each since 2020, far outpacing growth in most other states. Together, the two states now account for more than a third of marketplace enrollment nationally.

A small chorus of Republican lawmakers — up for reelection next year, mostly in competitive races — have proposed an extension of the subsidies, urging Democrats to vote to reopen the government while simultaneously pleading with House Speaker Mike Johnson to work out a bipartisan deal that doesn’t allow them to simply lapse.

At Cleveland’s barbershops in Austin, about a third of his 18 employees rely on Obamacare coverage. He’s talked to them about their health insurance options for next year but said many hadn’t started thinking about open enrollment, which began Nov. 1.

He’s worried they’ll be baffled once they see the new prices, which currently reflect what customers will pay next year without an extension of the extra subsidies.

“There’s a couple of my barbers that are going to go without, because they’re healthy and young, but I thought I was too when everything happened to me,” said Cleveland, now 47.

Republicans, meanwhile, remain wary of voting to extend the additional Obamacare subsidies, said Rodney Whitlock, a vice president at the McDermott+ consultancy who was a longtime congressional staffer and advises on health care policy.

No Republican voted for the extra subsidies when they were introduced in 2021 or continued in 2022. Approving them now, he said, is viewed by many as a band-aid that would temporarily help a program GOP leaders have long lambasted as problematic and too costly.

But, Whitlock noted, many in the party are coming to terms with how the subsidies might affect their changing constituencies. Nearly 6 in 10 Obamacare enrollees live in a Republican-held congressional district.

“Republicans are slowly starting to grasp that the lower third of income earners are their voters,” he said. “For the first time, I think they’re getting there. That battleship turns slowly.”

Rep. Marjorie Taylor Greene, a Georgia Republican who has firmly backed Trump, broke with her party last month, calling on the GOP to extend the subsidies. Greene said in an interview that rising health care costs are the “No. 1 issue” she hears about from people living in her district.

“I know a lot of small-business owners, like a family of four, and they’re paying $2,000 a month,” Greene said during the television interview, adding that rising deductibles make the insurance hardly functional for anything other than catastrophes.

She warned in another TV interview that “ignoring” the issue could be “very bad for midterms” next year.

Miller, the farmer who lives in a conservative district in Northern California, expects monthly health insurance premiums for himself, his wife, and two of his children to jump from $264 to $600. His deductibles and copayments are going up, too. He expects all these new expenses will still be on his mind when he goes to vote in the midterm elections next year, he said. Describing himself as an independent, Miller said he is frustrated that few American politicians talk about the type of universal health care coverage that’s available in other countries.

“I’m definitely voting for those that will protect the working American, regardless of party,” he said.

A photo of Justin Miller at his farmers market stand. Pumpkins and squash are seen on the table.
Miller expects the rising cost of health insurance will be on his mind when next year’s midterm elections roll around. “I’m definitely voting for those that will protect the working American, regardless of party,” he says.(Anne Chadwick Williams for KFF Health News)



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Five things to know about the dangers of high blood pressure

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Credit: Unsplash/CC0 Public Domain

It’s been nearly a decade since tens of millions of Americans awoke to a new diagnosis: high blood pressure.

The American Heart Association and the American College of Cardiology released guidelines in 2017 lowering the threshold for , or , from 140/90 to 130/80. Nearly half of all U.S. adults—about 120 million—have hypertension under those definitions. And more than three-quarters of them don’t have that high blood pressure under control, defined as under 130/80, according to the Centers for Disease Control and Prevention.

Blood pressure readings consist of two numbers. The top number, or systolic blood pressure, measures the pressure your blood puts against your artery walls when your heart beats. The bottom number, or , is a readout of that same pressure when your heart is at rest.

In August 2025, the American Heart Association and the American College of Cardiology released another update to their guidelines. This one was less dramatic—the definition of hypertension remains the same. But in the years since the last guideline update, researchers have uncovered more about the dangers of high blood pressure, as well as new ways to get it under control, both of which are reflected in the new revision.

To distill the 100-plus page guideline update into practical tips for Insights readers, we asked David Lee, MD, professor of cardiovascular medicine, to weigh in on why we should care about hypertension, how to get it under control, and to what extent wearable technology should be involved in monitoring our blood pressure.

1. Yes, you should care about your blood pressure

If there’s one overarching idea that hasn’t changed as hypertension guidelines are revised, it’s that high blood pressure is bad news. Researchers have known for a while that hypertension raises the risk of stroke and . More recent studies, however, showed that even small changes can have significant impacts.

A large study published in 2015 showed that for patients at increased risk of heart disease, more aggressive treatment that lowered their systolic blood pressure (the top number) to 120 prevented more heart attacks and deaths than treatment that lowered that number to under 140.

On its own, high blood pressure is a risk factor for heart disease, and conditions such as coronary artery disease or diabetes can boost a person’s risk even further. The 2015 study was partially responsible for the lowering of hypertension criteria from 140/90 to 130/80 in 2017. Those guidelines also created a new category, elevated blood pressure, which captures those with a between 121 and 129 and a diastolic pressure of 80 or less. Normal is now considered 120/80 or below.

“If you’re in a normal blood pressure range, your risk of having a heart attack or stroke is actually very low,” Lee said. “Once your blood pressure starts climbing, then that risk goes up two, five, eight times, depending on how high the blood pressure is.”

Hypertension can also raise the risk of other health problems, including kidney disease and dementia. The link between blood pressure and cognitive decline is now very clear—several recent studies have found that lowering blood pressure can reduce the risk of Alzheimer’s disease and other forms of dementia.

The guidelines now also recommend that pregnant people with hypertension should always be treated, although the cutoffs for high blood pressure in pregnancy are slightly higher than those for other adults. Hypertension can lead to a dangerous pregnancy condition known as pre-eclampsia or other problems for the mother or baby. Many can’t be used during pregnancy, but there are some that are safe.

2. Lifestyle changes may be enough to lower blood pressure

If someone has hypertension, their doctor may recommend lifestyle tweaks before trying medical approaches, Lee said—especially if the blood pressure is between 130/80 and 139/89. Even in healthy adults, blood pressure tends to increase with age; U.S. adults have an 80% chance of having hypertension at some point in their lives, according to the guidelines.

Recommended lifestyle approaches to high blood pressure include: losing weight, for those who are overweight or obese; exercising, both cardio and strength training; reducing salt in the diet; reducing alcohol consumption to one drink per day or less for women and two or fewer for men; and stress reduction techniques such as meditation or breathing exercises. All of these interventions have been shown to lower blood pressure, although stress reduction showed the smallest effects. These approaches can all also be used to prevent hypertension in people with normal blood pressure.

Usually, doctors will ask patients to try a lifestyle intervention for six months and see if it’s sufficient, Lee said. But adding another treatment doesn’t let a person off the hook. “We still keep working on those lifestyle issues even after you’ve started a medication,” he said.

3. Effective medical interventions exist

If haven’t lowered blood pressure, or if a patient’s readings are 140/90 or greater, their doctor will likely recommend medication, Lee said. There are several classes of blood pressure drugs, also called antihypertensives, and several different medications in each class. These include diuretics, which help the body eliminate salt and water; beta-blockers, which lower the heart rate; and several others that relax blood vessels or the muscles surrounding blood vessels, which lower the fluid pressure.

It can be a long process to find the right medication, dose, or combination of medications, usually involving frequent doctor visits as drugs or dosages are tweaked. Overcorrecting high blood pressure is not benign, especially in older adults, for whom can increase the risk of falling due to dizziness.

“One of the things we’ve learned is that if you try to get too aggressive with lowering the numbers, some bad things can happen,” Lee said. “We have to find the sweet spot.”

With some persistence, most adults will find the right medication to control hypertension. But for some, drugs don’t seem to work, Lee said. Researchers estimate that around 15% of people with hypertension have what is known as resistant hypertension.

In 2023, the first procedure to treat resistant hypertension was approved by the Food and Drug Administration. Known as renal denervation, it involves snaking a catheter from the femoral artery in the thigh into the arteries of the kidney, then using ultrasound or radiofrequency to destroy some of the nerves in those blood vessels. These nerves are part of the sympathetic nervous system, which regulates internal processes like heart rate and blood pressure. For some, removing some of the renal nerves can lower blood pressure, although these patients typically still need to take medication.

There are also several kinds of new antihypertensive medications being tested in clinical trials, said Lee, who has led trials testing the radiofrequency device. “A lot of energy has been brought back into treating high blood pressure,” Lee said. “There’s a new horizon for patients who have difficulty managing their blood pressure.”

4. At-home monitoring is the future, but not all devices are created equal

Although it’s a vital piece of health data, getting an accurate blood pressure reading is not trivial. If someone has a single abnormal reading in their doctor’s office, experts say more follow-up readings are needed before they can be truly diagnosed with hypertension. And what’s often called “white coat hypertension”—blood pressure that is high at the doctor’s office but normal otherwise—could account for 15% to 30% of people who have a high reading in the clinic.

Traditionally, doctors use ambulatory blood-pressure monitoring to confirm a hypertension diagnosis: Patients are lent a device that automatically records blood pressure for 24 hours. But personal blood pressure monitors are becoming more common, and tech companies are getting into the game—Apple recently announced that its smartwatches can signal hypertension.

The new guidelines don’t recommend cuffless monitoring like that in a smartwatch. But for those who want to use a blood pressure cuff at home, the measurements can be accurate if taken correctly (see chart). And this can cut down on the many doctor visits required when patients are fine-tuning their hypertension medications.

5. It takes a village to manage hypertension

In the U.S., many cases of hypertension fly under the radar. This is in part because high blood pressure rarely causes symptoms, so more than half of those who have hypertension have no idea. And more than 30% of U.S. adults don’t have a source of primary care, according to the Robert Graham Center, so they’re not getting regular blood pressure checks.

Even for those who have a primary care provider, trying and tweaking medication can be onerous for both patient and provider due to the number of office visits or other touchpoints required. And, as with most chronic conditions, adherence to hypertension medication is low—one study found that around half who were prescribed an antihypertensive had stopped taking it a year later.

High blood pressure is a common problem with a complex set of solutions. Even those who have a primary care provider may need more than one clinician to solve the problem. The guidelines now emphasize team-based care for hypertension, expanding the responsibility beyond primary care physicians to include nurses, pharmacists, dietitians, and community health workers.

Team care could also include increased home-based monitoring, telehealth, and electronic communication. And health care systems can collaborate with community programs to offer more blood pressure screening in non-clinical settings.

“It is a silent disease, so we have to do more to encourage community awareness,” Lee said. “We need to be a little more creative to reach out to people who don’t have easy access to good health care.”

Tips for getting an accurate blood pressure reading at home

We’re not quite at the point where your smartwatch or phone can give accurate , Lee said. For now, home monitoring should still be done with an automatic cuff device that fits on your upper arm. Here are some tips for making sure that reading is as accurate as possible, according to the American Heart Association:

  • Don’t exercise, smoke, or consume caffeine 30 minutes before measuring.
  • Empty your bladder.
  • Sit in a chair with both feet on the ground and your back supported.
  • Relax and sit still for five minutes before measuring, without talking or using your phone.
  • Take at least two measurements one minute apart.
  • Talk with your doctor about how frequently to monitor your blood pressure and how to report the results.

Citation:
Five things to know about the dangers of high blood pressure (2025, November 6)
retrieved 6 November 2025
from https://medicalxpress.com/news/2025-11-dangers-high-blood-pressure.html

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part may be reproduced without the written permission. The content is provided for information purposes only.



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Five things to know about the dangers of high blood pressure

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It’s been nearly a decade since tens of millions of Americans awoke to a new diagnosis: high blood pressure.

The American Heart Association and the American College of Cardiology released guidelines in 2017 lowering the threshold for , or , from 140/90 to 130/80. Nearly half of all U.S. adults—about 120 million—have hypertension under those definitions. And more than three-quarters of them don’t have that high blood pressure under control, defined as under 130/80, according to the Centers for Disease Control and Prevention.

Blood pressure readings consist of two numbers. The top number, or systolic blood pressure, measures the pressure your blood puts against your artery walls when your heart beats. The bottom number, or , is a readout of that same pressure when your heart is at rest.

In August 2025, the American Heart Association and the American College of Cardiology released another update to their guidelines. This one was less dramatic—the definition of hypertension remains the same. But in the years since the last guideline update, researchers have uncovered more about the dangers of high blood pressure, as well as new ways to get it under control, both of which are reflected in the new revision.

To distill the 100-plus page guideline update into practical tips for Insights readers, we asked David Lee, MD, professor of cardiovascular medicine, to weigh in on why we should care about hypertension, how to get it under control, and to what extent wearable technology should be involved in monitoring our blood pressure.

1. Yes, you should care about your blood pressure

If there’s one overarching idea that hasn’t changed as hypertension guidelines are revised, it’s that high blood pressure is bad news. Researchers have known for a while that hypertension raises the risk of stroke and . More recent studies, however, showed that even small changes can have significant impacts.

A large study published in 2015 showed that for patients at increased risk of heart disease, more aggressive treatment that lowered their systolic blood pressure (the top number) to 120 prevented more heart attacks and deaths than treatment that lowered that number to under 140.

On its own, high blood pressure is a risk factor for heart disease, and conditions such as coronary artery disease or diabetes can boost a person’s risk even further. The 2015 study was partially responsible for the lowering of hypertension criteria from 140/90 to 130/80 in 2017. Those guidelines also created a new category, elevated blood pressure, which captures those with a between 121 and 129 and a diastolic pressure of 80 or less. Normal is now considered 120/80 or below.

“If you’re in a normal blood pressure range, your risk of having a heart attack or stroke is actually very low,” Lee said. “Once your blood pressure starts climbing, then that risk goes up two, five, eight times, depending on how high the blood pressure is.”

Hypertension can also raise the risk of other health problems, including kidney disease and dementia. The link between blood pressure and cognitive decline is now very clear—several recent studies have found that lowering blood pressure can reduce the risk of Alzheimer’s disease and other forms of dementia.

The guidelines now also recommend that pregnant people with hypertension should always be treated, although the cutoffs for high blood pressure in pregnancy are slightly higher than those for other adults. Hypertension can lead to a dangerous pregnancy condition known as pre-eclampsia or other problems for the mother or baby. Many can’t be used during pregnancy, but there are some that are safe.

2. Lifestyle changes may be enough to lower blood pressure

If someone has hypertension, their doctor may recommend lifestyle tweaks before trying medical approaches, Lee said—especially if the blood pressure is between 130/80 and 139/89. Even in healthy adults, blood pressure tends to increase with age; U.S. adults have an 80% chance of having hypertension at some point in their lives, according to the guidelines.

Recommended lifestyle approaches to high blood pressure include: losing weight, for those who are overweight or obese; exercising, both cardio and strength training; reducing salt in the diet; reducing alcohol consumption to one drink per day or less for women and two or fewer for men; and stress reduction techniques such as meditation or breathing exercises. All of these interventions have been shown to lower blood pressure, although stress reduction showed the smallest effects. These approaches can all also be used to prevent hypertension in people with normal blood pressure.

Usually, doctors will ask patients to try a lifestyle intervention for six months and see if it’s sufficient, Lee said. But adding another treatment doesn’t let a person off the hook. “We still keep working on those lifestyle issues even after you’ve started a medication,” he said.

3. Effective medical interventions exist

If haven’t lowered blood pressure, or if a patient’s readings are 140/90 or greater, their doctor will likely recommend medication, Lee said. There are several classes of blood pressure drugs, also called antihypertensives, and several different medications in each class. These include diuretics, which help the body eliminate salt and water; beta-blockers, which lower the heart rate; and several others that relax blood vessels or the muscles surrounding blood vessels, which lower the fluid pressure.

It can be a long process to find the right medication, dose, or combination of medications, usually involving frequent doctor visits as drugs or dosages are tweaked. Overcorrecting high blood pressure is not benign, especially in older adults, for whom can increase the risk of falling due to dizziness.

“One of the things we’ve learned is that if you try to get too aggressive with lowering the numbers, some bad things can happen,” Lee said. “We have to find the sweet spot.”

With some persistence, most adults will find the right medication to control hypertension. But for some, drugs don’t seem to work, Lee said. Researchers estimate that around 15% of people with hypertension have what is known as resistant hypertension.

In 2023, the first procedure to treat resistant hypertension was approved by the Food and Drug Administration. Known as renal denervation, it involves snaking a catheter from the femoral artery in the thigh into the arteries of the kidney, then using ultrasound or radiofrequency to destroy some of the nerves in those blood vessels. These nerves are part of the sympathetic nervous system, which regulates internal processes like heart rate and blood pressure. For some, removing some of the renal nerves can lower blood pressure, although these patients typically still need to take medication.

There are also several kinds of new antihypertensive medications being tested in clinical trials, said Lee, who has led trials testing the radiofrequency device. “A lot of energy has been brought back into treating high blood pressure,” Lee said. “There’s a new horizon for patients who have difficulty managing their blood pressure.”

4. At-home monitoring is the future, but not all devices are created equal

Although it’s a vital piece of health data, getting an accurate blood pressure reading is not trivial. If someone has a single abnormal reading in their doctor’s office, experts say more follow-up readings are needed before they can be truly diagnosed with hypertension. And what’s often called “white coat hypertension”—blood pressure that is high at the doctor’s office but normal otherwise—could account for 15% to 30% of people who have a high reading in the clinic.

Traditionally, doctors use ambulatory blood-pressure monitoring to confirm a hypertension diagnosis: Patients are lent a device that automatically records blood pressure for 24 hours. But personal blood pressure monitors are becoming more common, and tech companies are getting into the game—Apple recently announced that its smartwatches can signal hypertension.

The new guidelines don’t recommend cuffless monitoring like that in a smartwatch. But for those who want to use a blood pressure cuff at home, the measurements can be accurate if taken correctly (see chart). And this can cut down on the many doctor visits required when patients are fine-tuning their hypertension medications.

5. It takes a village to manage hypertension

In the U.S., many cases of hypertension fly under the radar. This is in part because high blood pressure rarely causes symptoms, so more than half of those who have hypertension have no idea. And more than 30% of U.S. adults don’t have a source of primary care, according to the Robert Graham Center, so they’re not getting regular blood pressure checks.

Even for those who have a primary care provider, trying and tweaking medication can be onerous for both patient and provider due to the number of office visits or other touchpoints required. And, as with most chronic conditions, adherence to hypertension medication is low—one study found that around half who were prescribed an antihypertensive had stopped taking it a year later.

High blood pressure is a common problem with a complex set of solutions. Even those who have a primary care provider may need more than one clinician to solve the problem. The guidelines now emphasize team-based care for hypertension, expanding the responsibility beyond primary care physicians to include nurses, pharmacists, dietitians, and community health workers.

Team care could also include increased home-based monitoring, telehealth, and electronic communication. And health care systems can collaborate with community programs to offer more blood pressure screening in non-clinical settings.

“It is a silent disease, so we have to do more to encourage community awareness,” Lee said. “We need to be a little more creative to reach out to people who don’t have easy access to good health care.”

Tips for getting an accurate blood pressure reading at home

We’re not quite at the point where your smartwatch or phone can give accurate , Lee said. For now, home monitoring should still be done with an automatic cuff device that fits on your upper arm. Here are some tips for making sure that reading is as accurate as possible, according to the American Heart Association:

  • Don’t exercise, smoke, or consume caffeine 30 minutes before measuring.
  • Empty your bladder.
  • Sit in a chair with both feet on the ground and your back supported.
  • Relax and sit still for five minutes before measuring, without talking or using your phone.
  • Take at least two measurements one minute apart.
  • Talk with your doctor about how frequently to monitor your blood pressure and how to report the results.

Citation:
Five things to know about the dangers of high blood pressure (2025, November 6)
retrieved 6 November 2025
from https://medicalxpress.com/news/2025-11-dangers-high-blood-pressure.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Source link